FIRST DAY

THURSDAY • OCTOBER 3, 2024

WELCOME AND INTRODUCTION
9:00 am - 9:15 am
Silvia C. Formenti, MD
Weill Cornell Medical College, New York, NY, USA

KEYNOTE LECTURE
9.15 am-10.00 am: The Dirty Secrets of Radiation Oncology
Laurence Zitvogel, MD, PhD
Gustave Roussy Cancer Center, Villejuif, France

10.00 am-10.30 am
Coffee break

CME-ACCREDITED PRIMER ON RADIATION THERAPY-INDUCED MODULATION OF THE TUMOR IMMUNE MICROENVIRONMENT
Supported by SITC  

Primer on Radiation Therapy-Induced Modulation of the Tumor Immune Microenvironment
Chair: Dr. Sandra Demaria

10.30 am-11.00 am: Novel Strategies to Addressing Checkpoint Resistance
James Welsh, MD
MD Anderson Cancer Center, Houston, TX, USA

 11.00 am-11.30 am: Low-dose RT as Strategy to Recruit T Cells to the Tumor Microenvironment
Fernanda Herrera, MD, PhD
Universite de Lausanne, Lausanne, Switzerland

 11.30 am-12.00 pm: Impact of Intestinal Low Dose Irradiation in response to Immunoradiotherapy
Eric Deutsch, MD
Gustave Roussy Cancer Center, Paris, France

 12.00 pm-12.30 pm: Emerging effects of radiation therapy on lymphocytes
Lorenzo Galluzzi, PhD
Weill Cornell Medical College, New York, NY, USA

12:30 pm – 2:00 pm
Lunch break

MAIN PROGRAM
Session I – Radiation Therapy and Antigen Presentation
Chairs: Dr. Timothy A. Chan, Dr. Padma Nanaware
Sponsored by Ankyra Therapeutics

2:00 pm – 2:30 pm: Effects of Radiation Therapy on Brain Lymphatics and Brain Proteostasis
Laura Santambrogio, PhD
Weill Cornell Medical College, New York, NY, USA

2:30 pm – 3:00 pm: Tumor Antigen Processing is Key to Immunity
Dörthe Schaue, PhD
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

3:00 pm – 3:30 pm: Modulating the Immunogenicity of Epithelial Cancers: Experiments with Cyclophosphamide and Radiation
Andrew Godkin, PhD
Cardiff University, Cardiff, Glamorgan, Wales, UK

3:30 pm – 4:00 pm
Coffee break

 Session II – Immune Inhibitory Effects of Radiation Therapy
Chairs: Dr. Lorenzo Galluzzi, Dr. Mara De Martino

4:00 pm – 4:30 pm: Reprogramming macrophages, a novel combination with focal radiotherapy
Nir Ben Chetrit, PhD
Weill Cornell Medical College, New York, NY, USA

4:30 pm – 5:00 pm: Neutrophil Biology and Radiation Therapy
Taha Merghoub, PhD
Weill Cornell Medical College, New York, NY, USA

5:00 pm – 5:30 pm: Ferroptosis regulation of MDSC in cancer
Dmitry I. Gabrilovich, MD, PhD
Astra Zeneca, Gaithersburg, MD, USA

5:30 pm
End of Day 1

6:00 pm – 8:00pm: Poster Session Reception

SECOND DAY

FRIDAY • OCTOBER 4, 2024

Session III – Short Talks – Selected from Abstract
Chair: Dr. Claire Vanpouille-Box

8:30 am – 8:45 am: Leveraging immune engagement triggered by FLASH radiotherapy for tumor control
Anne-Galle-Goubet, PharmD-PhD
University of Geneva, Geneva, Switzerland

8:45 am – 9:00 am: The role of DNA damage activated NF-kB in radiation induced anti-tumor immunity
Donna Li
University of Wisconsin-Madison, Wisconsin, US

 Session IV– Rectal Cancer as a Model for Studying RT-Induced Immune Modulation
Chairs: Dr. John Ng, Dr. Maud Charpentier

9:00 am – 9:30 am: Adenosine Blockade plus RT in Rectal Cancer
Encouse Golden, MD, PhD
Weill Cornell Medical College, New York, NY, USA

9:30 am – 10:00 am: The T Cell Receptor Engagement Dynamics of the Anti-viral Immune Response: A Potential Marker of Anti-tumour Immune Activation Following Neoadjuvant Radiotherapy for Rectal Cancer
Alan A. Melcher, PhD
Institute for Cancer Research, London, UK

10:00 am – 10:30 am: TGFβ Neutralization plus RT in Rectal Cancer
Kristina H. Young, MD, PhD
Providence Cancer Center, Portland, OR, USA

10:30 am – 11:00 am
Coffee break

Session V – Radiation Therapy and Immunotherapy in the Management of Solid Tumors
Chairs: Dr. Rie Nygaard, Dr. Claudia Galassi

11:00 am - 11:30 am: Modulators of Radiation-Immunotherapy Synergy in Breast Cancer
Gaorav P. Gupta, MD, PhD
University of North Carolina, Chapel Hill, NC, USA

11:30 am – 12:00 am: Activating Immune Responses Against Small-cell Lung Cancer
Julien Sage, PhD
Stanford University, Stanford, CA, USA

12:00 pm – 12:30 pm: How Do We Target the Bladder Tumor Microenvironment to Improve Radiotherapy Outcomes?
Anna Wilkins, MD, PhD
Institute of Cancer Research, London, UK

12:30 – 2:00 pm
Lunch break

Session VI – Role of Radiotherapy and Immunotherapy Combinations in Metastatic Disease
Chairs: Dr. James Welsh, Dr. Maria Cecilia Lira

2:00 pm – 2:30 pm: Radiotherapy and Immunotherapy: Beyond Checkpoint Inhibitors
Arta Monjazeb, MD
UCDavis School of Medicine, USA

2:30 pm – 3:00 pm: Role of EVs in Radiotherapy
Julie Constanzo, PhD
Institut du Cancer de Montpellier, Montpellier, France

3:00 pm – 3:30 pm: Immunogenomic Response to Combination SBRT and Immune Checkpoint Blockade in Metastatic NSCLC
Sean Pitroda, MD, PhD
University of Chicago, Chicago, IL, USA

3:30 pm – 4:00 pm
Coffee break

Session VII – Cancer Immunogenomics and Radiation Therapy
Chairs: Dr. Wen Shen, Dr. Ines Mota

4:00 pm – 4:30 am: Mutations, DNA Damage Repair, and Mechanisms Underlying Immunotherapy Efficacy
Timothy A. Chan, MD, PhD
Cleveland Clinic, Cleveland, OH, USA                                             

4:30 pm – 5:00 pm: AI and Single Cell Data Analysis to Understand Response to Therapies
Anguraj Sadanandam, PhD
Institute for Cancer Research, London, UK

5:00 pm – 5:30 pm: Tumor Microenvironment in Immunotherapy Resistance
Brian D. Brown, PhD  
Mount Sinai Medical Center, New York, NY

5:30 pm
End of Day 2

 6:00 pm – 8:00pm: Social Event – Harbor Dinner Cruise

THIRD DAY

SATURDAY • OCTOBER 5, 2024

Session VIII – Short Talks – Selected from Abstract
Chair: Dr. Julie Constanzo

8:30 am – 8:45 am: Synergistic Effects of Pembrolizumab and Radiation Therapy in Early-Stage Triple-Negative Breast Cancer: Insights from the P-RAD Clinical Trial and Preclinical Autochthonous Murine Model
Sierra McDonald, PhD
University of North Carolina School of Medicine, North Carolina, US

8:45 am – 9:00 am: ART1: A hidden player in radiotherapy-immunotherapy resistance
Erik Wennerberg, PhD
Institute for Cancer Research, London, UK

Session IX – Novel approaches
Chairs: Dr. Encouse Golden, Diego Sialer

9:00 am – 9:30 am: Relative Immunological Effectiveness of Carbon Ion Radiation Therapy
Chandan Guha, PhD
Albert Einstein College of Medicine, New York, USA             

9:30 am – 10:00 am: Approach to Radiation Therapy in the Era of Immunotherapy
Aisha Hasan
Johnson & Johnson, USA

10:00 am – 10:30 pm: Dendritic Cells Accelerate CAR T Cells Through Chimeric Synapses in Irradiated Tumors
Jalal Ahmed
Icahn School Of Medicine at Mount Sinai, New York, USA

10:30 am – 11:00 am
Coffee break

PANEL DISCUSSION

11:00 am – 12:00 pm
Silvia C. Formenti, MD
Weill Cornell Medical College, New York, NY, USA

Eric Deutsch, MD
Gustave Roussy Cancer Center, Paris, France       

Philippe Szapary, MD MSCE
Johnson & Johnson, USA

Sebastien Paris, PhD
Nanobiotix, USA

Howard Kaufman, MD
Ankyra Therapeutics, USA

Dhan Chand, MD
Agenus Bio, USA

CONCLUDING REMARKS
12:00 pm - 12:15 pm
Eric Deutsch, MD, PhD
Gustave Roussy Cancer Center, Paris, France

12:15 pm
End of Day 3