Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors

Xiaowei Bian ^1,13, Minna Piipponen^1,13, Zhuang Liu¹, Lihua Luo ¹, Jennifer Geara¹,Yongjian Chen¹, Traimate Sangsuwan², Monica Maselli¹, Candice Diaz^3,4,Connor A. Bain⁵, Evelien Eenjes⁶, Maria Genander ⁶, Michael Crichton⁵,Jenna L. Cash⁷, Louis Archambault⁸, Siamak Haghdoost^2,9, Julie Fradette^3,4,10,Pehr Sommar^11,12, Martin Halle ^11,12,14 & Ning Xu Landén ^1,14

⚡New publication in Nature #Communication revealing that #radiotherapy impairs #wound healing in #cancer survivors by altering the chromatin landscape of dermal #fibroblasts, leading to #epigenetic memory.

Researchers identified THBS1 as a key gene involved in this process and demonstrated that anti-THBS1 antibodies can improve wound healing in RT-affected skin.

These findings offer promising therapeutic avenues to enhance the quality of life for cancer survivors.

Read more : Nature